KEGG   Homo sapiens (human): 4360
Entry
4360              CDS       T01001                                 
Symbol
MRC1, CD206, CLEC13D, CLEC13DL, MMR, MRC1L1, bA541I19.1, hMR
Name
(RefSeq) mannose receptor C-type 1
  KO
K06560  mannose receptor, C type
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa05152  Tuberculosis
Drug target
Technetium (99mTc) tilmanocept: D11543<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    4360 (MRC1)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    4360 (MRC1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4360 (MRC1)
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:hsa04054]
    4360 (MRC1)
   04090 CD molecules [BR:hsa04090]
    4360 (MRC1)
   04091 Lectins [BR:hsa04091]
    4360 (MRC1)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   C-lectin receptors
    4360 (MRC1)
Pattern recognition receptors [BR:hsa04054]
 Membrane-bound pattern recognition receptors
  C-type lectin receptors
   4360 (MRC1)
CD molecules [BR:hsa04090]
 Proteins
  4360 (MRC1)
Lectins [BR:hsa04091]
 C-Type lectins
  Group 6: Mannose receptor family
   4360 (MRC1)
SSDB
Motif
Pfam: Lectin_C fn2 Ricin_B_lectin Xlink UL45 CDtoxinA
Other DBs
NCBI-GeneID: 4360
NCBI-ProteinID: NP_002429
OMIM: 153618
HGNC: 7228
Ensembl: ENSG00000260314
UniProt: P22897
Structure
Position
10:17809348..17911164
AA seq 1456 aa
MRLPLLLVFASVIPGAVLLLDTRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRW
VSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYG
NRQEKNIMLYKGSGLWSRWKIYGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYA
DCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPLTSVSYQINSKSALTW
HQARKSCQQQNAELLSITEIHEQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRY
LNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTLNSFVIPSESDVPT
HCPSQWWPYAGHCYKIHRDEKKIQRDALTTCRKEGGDLTSIHTIEELDFIISQLGYEPND
ELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKGKDGYWADRGCEW
PLGYICKMKSRSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTFAEANQTCNNENAYLT
TIEDRYEQAFLTSFVGLRPEKYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGRKPGC
VAMRTGIAGGLWDVLKCDEKAKFVCKHWAEGVTHPPKPTTTPEPKCPEDWGASSRTSLCF
KLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYG
SPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQ
KGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQS
ESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCV
TMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIF
GFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTF
LWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQ
TRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNA
FAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWK
TAHCNESFYFLCKRSDEIPATEPPQLPGRCPESDHTAWIPFHGHCYYIESSYTRNWGQAS
LECLRMGSSLVSIESAAESSFLSYRVEPLKSKTNFWIGLFRNVEGTWLWINNSPVSFVNW
NTGDPSGERNDCVALHASSGFWSNIHCSSYKGYICKRPKIIDAKPTHELLTTKADTRKMD
PSKPSSNVAGVVIIVILLILTGAGLAAYFFYKKRRVHLPQEGAFENTLYFNSQSSPGTSD
MKDLVGNIEQNEHSVI
NT seq 4371 nt   +upstreamnt  +downstreamnt
atgaggctacccctgctcctggtttttgcctctgtcattccgggtgctgttctcctactg
gacaccaggcaatttttaatctataatgaagatcacaagcgctgcgtggatgcagtgagt
cccagtgccgtccaaaccgcagcttgcaaccaggatgccgaatcacagaaattccgatgg
gtgtccgaatctcagattatgagtgttgcatttaaattatgcctgggagtgccatcaaaa
acggactgggttgctatcactctctatgcctgtgactcaaaaagtgaatttcagaaatgg
gagtgcaaaaatgacacacttttggggatcaaaggagaagatttattttttaactacggc
aacagacaagaaaagaatattatgctctacaagggatcgggtttatggagcaggtggaag
atctatggaaccacagacaatctgtgctccagaggttatgaagccatgtatacgctacta
ggcaatgccaatggagcaacctgtgcattcccgttcaagtttgaaaacaagtggtacgca
gattgcacgagtgctgggcggtcggatggatggctctggtgcggaaccactactgactat
gacacagacaagctatttggatattgtccattgaaatttgagggcagtgaaagcttatgg
aataaagacccgctgaccagcgtttcctaccagataaactccaaatccgctttaacgtgg
caccaggcgaggaaaagctgccaacaacagaacgctgagctcctgagcatcacagagatt
catgagcaaacatacctgacaggattaaccagttccttgacctcaggactctggattgga
cttaacagtctgagcttcaacagcggttggcagtggagtgaccgcagtcctttccgatat
ttgaactggttaccaggaagtccatcagctgaacctggaaaaagctgtgtgtcactaaat
cctggaaaaaatgctaaatgggaaaatctggaatgtgttcagaaactgggctatatttgc
aaaaagggcaacaccactttaaattcttttgttattccctcagaaagtgatgtgcctact
cactgtcctagtcagtggtggccgtatgccggtcactgttacaagattcacagagatgag
aaaaaaatccagagggatgctctgaccacctgcaggaaggaaggcggtgacctcacaagt
atccacaccatcgaggaattggactttattatctcccagctaggatatgagccaaatgac
gaattgtggatcggcttaaatgacattaagattcaaatgtactttgagtggagtgatggg
acccctgtaacgtttaccaaatggcttcgtggagaaccaagccatgaaaacaacagacag
gaggattgtgtggtgatgaaaggcaaggatgggtactgggcagatcggggctgtgagtgg
cctcttggctacatctgcaagatgaaatcacgaagccaaggtccagaaatagtggaagtc
gaaaaaggctgcaggaaaggctggaaaaaacatcacttttactgctatatgattggacat
acgctttcaacatttgcagaagcaaaccaaacctgtaataatgagaatgcttatttaaca
actattgaagacagatatgaacaagccttcctgactagtttcgttggcttaaggcctgaa
aaatatttctggacaggactttcagatatacaaaccaaagggacttttcagtggaccatc
gaggaagaggttcggttcacccactggaattcagatatgccagggcgaaagccagggtgt
gttgccatgagaaccgggattgcagggggcttatgggatgttttgaaatgtgatgaaaag
gcaaaatttgtgtgcaagcactgggcagaaggagtaacccacccaccgaagcccacgacg
actcccgaacccaaatgtccggaggattggggcgccagcagtagaacaagcttgtgtttc
aagctgtatgcaaaaggaaaacatgagaagaaaacgtggtttgaatctcgagatttttgt
cgagctctgggtggagacttagctagcatcaataacaaagaggaacagcaaacaatatgg
cgattaataacagctagtggaagctaccacaaactgttttggttgggattgacatatgga
agcccttcagaaggttttacttggagtgatggttctcctgtttcatatgaaaactgggct
tatggagaacctaataattatcaaaatgttgaatactgtggtgagctgaaaggtgaccct
actatgtcttggaatgatattaattgtgaacaccttaacaactggatttgccagatacaa
aaaggacaaacaccaaaacctgagccaacaccagctcctcaagacaatccaccagttact
gaagatgggtgggttatttacaaagactaccagtattatttcagcaaagagaaggaaacc
atggacaatgcgcgagcgttttgcaagaggaattttggtgatcttgtttctattcaaagt
gaaagtgaaaagaagtttctatggaaatatgtaaacagaaatgatgcacagtctgcatat
tttattggtttattgatcagcttggataaaaagtttgcttggatggatggaagcaaagtg
gattacgtgtcttgggccacaggtgaacccaattttgcaaatgaagatgaaaactgtgtg
accatgtattcaaattcagggttttggaatgacattaactgtggctatccaaacgccttc
atttgccagcgacataacagtagtatcaatgctaccacagttatgcctaccatgccctcg
gtcccatcagggtgcaaggaaggttggaatttctacagcaacaagtgtttcaaaatcttt
ggatttatggaagaagaaagaaaaaattggcaagaggcacgaaaagcttgtataggcttt
ggagggaatctggtctccatacaaaatgaaaaagagcaagcatttcttacctatcacatg
aaggactccactttcagtgcctggactgggctgaatgatgtcaattcagaacacacgttc
ctttggacggatggacgaggagtccattacacaaactgggggaaaggttaccctggtgga
agaagaagcagtctttcttatgaagatgctgactgtgttgttattattggaggtgcatca
aatgaagcaggaaaatggatggatgatacctgcgacagtaaacgaggctacatatgccag
acacgatccgacccttccttgactaatcctccagcaacgattcaaacagatggctttgtt
aaatatggcaaaagcagctattcactcatgagacaaaaatttcaatggcatgaagcggag
acatactgcaagcttcacaattcccttatagccagcattctggatccctacagtaatgca
tttgcgtggctgcagatggaaacatctaatgaacgtgtgtggatcgccctgaacagtaac
ttgactgataatcaatacacttggactgataagtggagggtgaggtacactaactgggct
gctgatgagcccaaattgaaatcagcatgtgtttatctggatcttgatggctactggaag
acagcacattgcaatgaaagtttttactttctctgtaaaagatcagatgaaatccctgct
actgaacccccacaactgcctggcagatgcccggagtcagatcacacagcatggattcct
ttccatggtcactgttactatattgagtcctcatatacaagaaactggggccaagcttct
ctggaatgtcttcgaatgggttcctctctggtttccattgaaagtgctgcagaatccagt
tttctgtcatatcgggttgagccacttaaaagtaaaaccaatttttggataggattgttc
agaaatgttgaagggacgtggctgtggataaataacagtccggtctcctttgtcaactgg
aacacaggagatccctctggtgaacggaatgattgtgtagctttacatgcgtcttctggg
ttttggagtaatattcactgttcatcctacaaaggatatatttgtaaaagaccaaaaatt
attgatgctaaacctactcatgaattacttacaacaaaagctgacacaaggaagatggac
ccttctaaaccgtcttccaacgtggccggagtagtcatcattgtgatcctcctgatttta
acgggtgctggccttgccgcctatttcttttataagaaaagacgtgtgcacctacctcaa
gagggcgcctttgaaaacactctgtattttaacagtcagtcaagcccaggaactagtgat
atgaaagatctcgtgggcaatattgaacagaatgaacactcggtcatctag

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (34)   
   KEGG ORTHOLOGY (1)   
   RefGene (28)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (26)   
   RefSeq(nuc) (2)   
   GenBank (12)   
   EMBL (12)   
3D Structure (24)   
   PDB (24)   
Protein domain (6)   
   Pfam (6)   
All databases (103)   

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